Table 1.

Statistical assessment of AD diagnostic accuracy for CSF tau and AD7C-NTP

MarkerTechniqueAD vs PDAD vs HCAD vs CON
* Receiver operating characteristics analysis: area under the curve (AUC) and standard error (SE), cutoff given for sum of sensitivity and specificity maximized.
† Multivariate stepwise discriminant analysis: a priori probability of group membership assumed equal; sensitivity and specificity estimated from all cases in the equation.
‡ Patients with AD (n = 30), patients with PD (n = 29), HC (healthy control subjects) (n = 16), CON (healthy control subjects and patients with PD combined) (n = 45).
AD7C-NTPROC*
AUC (SE)0.805 (0.057)0.748 (0.072)0.784 (0.056)
Cutoff2.48–2.51 ng/mL2.07–2.11 ng/mL2.48–2.51 ng/mL
Sensitivity707770
Specificity908187
TauROC*
AUC (SE)0.771 (0.062)0.782 (0.067)0.775 (0.058)
Cutoff0.53–0.55 ng/mL0.45–0.55 ng/mL0.53-0.55 ng/ML
Sensitivity (%)636363
Specificity (%)967589
Tau, AD7C-NTPDISCRIM
Sensitivity (%)776063
Specificity938193