Table 3.

Baseline NIH Stroke Scale (NIHSS) by time from stroke onset to treatment (onset-to-treatment time [OTT]) strata and treatment group

NIHSSOTT stratap Value*
0–90 Minute, n = 30291–180 Minute, n = 320
rt-PAPlacebort-PAPlacebo
* p Value associated with test of the OTT strata by treatment interaction using analysis of variance on ranked data with NIHSS as the outcome. The presence of an interaction implies the NIHSS magnitude varies by OTT and treatment strata.
rt-PA = recombinant tissue-type plasminogen activator.
No. of patients157145153167
NIHSS, mean (SD); median15.2 (7.2); 1515.0 (6.7); 1413.5 (7.7); 1215.4 (6.9); 150.06
NIHSS groups, percent0.03
0–58.36.219.04.2
6–1019.125.524.227.5
11–1524.821.417.021.0
16–2025.525.521.619.8
>2022.321.418.327.5