Table 1.

MRI volumes for the lacune and probable AD (prAD) groups, and their respective controls

CharacteristicsCognitively normal lacune (CN+L)Controls (NC) for CN+LCognitively impaired lacune (CI+L)Controls (NC) for CI+LDemented lacune (D+L)prAD (demented, no lacunes)Controls for D+L and prAD
Values are mean (SD). Significantly different from controls at %* p < 0.05,
p < 0.01,
p < 0.0001. Significantly different from prAD at %a p < 0.05,
bp < 0.0001.
MMSE = Mini-Mental State Examination; GM = gray matter; WMSH = white matter signal hyperintensities.
Men/women16/1612/1524/217/516/1313/1514/9
Age, y75 (6)73 (7)72 (8)72 (8)77 (8)76 (7)76 (7)
MMSE28.9 (1.2)29.1 (0.9)27.7 (2.5)*29.1 (1.0)21.3 (4.0)21.3 (5.5)29.3 (0.9)
Cortical GM %38.1 (2.9)39.3 (2.6)37.1 (3.0)*38.8 (2.2)34.5 (2.6)35.7 (2.5)38.7 (2.3)
White matter %36.2 (3.3)36.3 (2.2)35.0 (2.6)35.7 (2.6)34.5 (3.5)33.9 (3.1)*35.4 (2.1)
WMSH %1.2 (1.4)0.5 (0.6)1.4 (1.2)0.5 (0.6)2.5 (2.2)b0.6 (0.4)0.6 (0.6)
Ventricular CSF %3.9 (1.3)3.8 (1.8)4.7 (1.7)4.0 (1.8)6.8 (2.2)a5.4 (1.9)*4.1 (1.7)
Sulcal CSF %20.4 (3.1)19.3 (3.4)21.9 (3.2)20.2 (3.4)23.1 (4.4)*23.9 (4.2)20.5 (3.2)
Hippocampal5892 (902)5876 (767)5380 (894)*5970 (834)4184 (926)3722 (857)5739 (831)
volume, mm3(n = 12/12)(n = 12/12)(n = 17/1)(n = 18/1)(n = 13/10)(n = 11/7)(n = 14/8)
Intracranial vault volume, cc1322 (131)1318 (144)1365 (160)1377 (127)1289 (162)1296 (156)1320 (142)