Table 3.

Regional cortical gray matter atrophy in the demented lacune (D+L) and probable AD (prAD) groups, compared to normal controls (NC) and to each other

Cortical regionD+L vs NCprAD vs NCD+L vs prAD
Values are % difference.
Significant at %* p < 0.05,
p < 0.01, and
p < 0.001.
Frontal
Orbital frontal and frontal pole−16.4−17.21.0
Lateral frontal−18.0−12.5−6.3*
Posterior frontal−9.4−5.5−4.1
Superior frontal−10.2−5.0*−5.5
Motor−10.6−1.3−9.4
Parietal
Lateral parietal−10.1−10.50.5
Mesial parietal−10.7−9.6−1.3
Sensory 1−10.0−6.2−4.1
Sensory 2−12.7−8.8*−4.3
Sensory 3−13.5−10.7−3.2
Occipital
Anterior occipital−15.5−10.4−5.6
Visual association−12.8−2.8−10.3*
Temporal
Anterior temporal−16.8−12.5−4.9
Superior temporal−18.9−13.4−6.3*
Inferior temporal−16.5−14.4−2.5
Limbic lobe−18.9−12.2−7.7