Table 2.

Allele and genotype distribution of −491 A/T polymorphism

GroupAllelesGenotypes
ATTotalAAATTTTotal
2 × 2 χ2 test for A allele: p < 0.0001, OR = 2.48.
2 × 2 χ2 test for AA genotype: p < 0.0001, OR = 2.76.
Controls (%)435 (79)113 (21)548170 (62)95 (35)9 (3)274
ε4 Carriers109 (83)23 (17)13244 (67)21 (32)1 (2)66
Non-ε4 carriers326 (78)90 (22)416126 (61)74 (36)8 (4)208
AD cases (%)429 (91)45 (9)474194 (82)41 (17)2 (1)237
ε4 Carriers236 (94)16 (6)252111 (88)14 (11)1 (1)126
Non-ε4 carriers189 (87)29 (13)21881 (74)27 (25)1 (1)109