Table 1.

Mean reduction of dyskinesias on low-dose olanzapine and placebo

MeasurePlacebo mean (SD)Olanzapine mean (SD)p Value (two-tailed significance)
AIMS = abnormal involuntary movement scale; UPDRS = Unified PD Rating Scale.
Objective dyskinesia ratings
% reduction AIMS scores−11 (38)30 (37)0.017
% reduction G3 scores−14 (58)33 (20)0.021
% reduction G8 scores−4 (22)24 (26)0.028
Subjective impression
% reduction diary scores−2 (29)46 (32)0.017
% reduction severity (UPDRS item 32)0 (13.5)33.5 (17.8)0.016
% reduction duration (UPDRS item 33)8.3 (17.7)35 (21)0.018
Improvement on 4-point scale0.3 (0.3)1.7 (1.0)0.026