Table 1.

Occurrence of 14-3-3 proteins in CSF of Creutzfeldt–Jakob disease (CJD) patients and of patients with other neurologic diseases (n = 1,003)

Disease14-3-3 positive
* Six related to human growth hormone, three dura mater, one corneal graft.
† Gerstmann–Sträussler–Scheinker disease.
‡ Fatal familial insomnia.
§ Family history, but no genotyping available.
¶ Three AD, three encephalitis, eight vascular disorders (three anoxia, two stroke, two subarachnoid hemorrhage, one brainstem infarction), one each of multiple myeloma, metabolic encephalopathy, lymphohistiocytoma, paraneoplastic encephalopathy, malignant meningitis, and one patient with cerebral ischemia whose CSF was taken within a few days of seizures. In the remaining 14 cases, no final diagnosis could be made; most of these patients had dementia, but their clinical features did not fulfill the criteria for classification as CJD.
Definite or probable CJD, n = 413376
Possible CJD, n = 12779
New variant CJD, n = 115
Iatrogenic CJD,* n = 106
Genetic/familial patients
P102L, n = 52
E200K, n = 1313
V210I, n = 1515
D178N-129M, n = 150
Familial,§ n = 21
Other neurologic diseases, n = 39234