Table 2.

Acute therapies for migraine

Group 1*Group 2†Group 3‡Group 4§Group 5¶
* Proven, pronounced statistical and clinical benefit (at least two double-blind, placebo-controlled studies and clinical impression of effect).
† Moderate statistical and clinical benefit (one double-blind, placebo-controlled study and clinical impression of effect).
‡ Statistically but not proven clinically or clinically but not proven statistically effective (conflicting or in consistent evidence).
§ Proven to be statistically or clinically ineffective (failed efficacy versus placebo).
Clinical and statistical benefits uknown (insufficient evidence available).
SpecificAcetaminophen plus codeine POButalbital, aspirin, plus caffeine POAcetaminophen PODexamethaxone IV
Naratriptan POButalbital, aspirin, caffeine, plus codeine POErgotamine POChlorpromazine IMHydrocortisone IV
Rizatriptan POButorphanol IMErgotamine plus caffeine POGranisetron IV
Sumatriptan SC, IN, POChlorpromazine IM, IVMetocloproamide IM, PRLidocraine IV
Zolmitriptan PODiclofenac K, PO
DHE SC, IM, IV, INErgotamine plus caffeine plus pentobarbital plus Bellafoline® PO
DHE IV, plus antiemeticFlurbiprofen, PO
NonspecificIsometheptene CPD, PO
Acetaminophen, aspirin, plus caffeine POKetorolac IM
Aspirin POLidocaine IN
Butorphanol INMeperidine IM, IV
Ibuprofen POMethadone IM
Naproxen sodium POMetoclopramide IV
Prochlorperazine IVNaproxen PO
Prochlorperazine IM, PR