Preventive therapies for migraine*
| Group 1† | Group 2‡ | Group 3§ | Group 4¶ | Group 5∥ |
|---|---|---|---|---|
| * Does not include combination products. | ||||
| † Medium to high efficacy, good strength of evidence, and mild-to-moderate side effects. | ||||
| ‡ Lower efficacy than those listed in first column, or limited strength of evidence, and mild-to-moderate side effects. | ||||
| § Clinically efficacious based on consensus and clinical experience, but no scientific evidence of efficacy. | ||||
| ¶ Medium to high efficacy, good strength of evidence, but with side effect concerns. | ||||
| ∥ Evidence indicating no efficacy over placebo. | ||||
| Amitriptyline | B-blockers | A: Antidepressants | Methysergide | Acebutolol |
| Divalproex sodium | Atenolol/metoprolol/nadolol | Doxepine | Carbamazepine | |
| Propranolol/timolol | Fluvoxamine | Clomipramine, clonazepam | ||
| Ca-blockers | Imipramine | Clonidine | ||
| Nimodipine/verapamil | Mirtazepine | Indomethacin | ||
| Nortriptyline | Nicardipine | |||
| NSAIDs | Paroxetine | Nifedipine | ||
| Aspirin/fenoprofen/flurbiprofen | Protriptyline | Pindolol | ||
| Ketoprofen | Sertraline trazodone | |||
| Mefenamic acid | Venlafaxine | |||
| Neproxen | Cyproheptadine diltiazem | |||
| Naproxen sodium | Ibuprofen | |||
| Fluoxetine (racemic) | Tiagabine | |||
| Gabapentine | Topiramate | |||
| Other | B: (side effect concerns) | |||
| Feverfew | Methylergonovine (methylergometrine) | |||
| Magnesium vitamin B2 | Phenelzine | |||