Table 1.

Dihydropyrimidine dehydrogenase (DPD) activity in peripheral blood mononuclear (PBM) cells and uracil levels in plasma and urine

ParametersPatientMean ± SD95% Range99% Range
* Mean, 95th, and 99th percentiles for DPD in PBM cells based on frozen samples.
† No established reference ranges for the normal population.
PBM–DPD (nmol/min/mg protein)*0.045000.189 ± 0.0640.064–0.3140.024–0.354
Plasma uracil (ng/mL)42.0027.28 ± 22.43<100
Urine uracil (ng/mL)44.478