Tau haplotype frequency in neuropathologically confirmed corticobasal degeneration (CBD) cases and controls
| Allele | CBD, n = 114 All cases | CBD, n = 60 USA | CBD, n = 28 Canada | CBD, n = 26 UK | Controls, n = 440 All controls | Controls, n = 290 USA | Controls, n = 150 UK | PSP, n = 128 |
|---|---|---|---|---|---|---|---|---|
| Values expressed as percent (number). Controls are age-matched. | ||||||||
| Chi-square analysis shows that there is a highly significant increase in H1 frequency in all CBD cases and in CBD cases analyzed by country of origin compared with their respective controls. The significance values derived from chi-square are as follows: all cases of CBD (p = 0.00255, 1 df), USA CBD (p = 0.0025, 1 df), Canadian CBD (p = 0.003, 1 df), and UK CBD (p = 0.0047, 1 df). Chi-square analysis shows that H1 frequency was not different from that of PSP; p = 0.66 (1 df). | ||||||||
| PSP = progressive supranuclear palsy; n = number of chromosomes. | ||||||||
| H1 | 92.1 (105) | 93.3 (56) | 92.9 (26) | 88.5 (23) | 76.6 (337) | 78.4 (228) | 72.7 (109) | 93.7 (120) |
| H2 | 7.9 (9) | 6.7 (4) | 7.1 (2) | 11.5 (3) | 23.4 (103) | 21.6 (62) | 27.3 (41) | 6.3 (8) |