Table 1.

Demographics and disease characteristics at beginning of year 3

CharacteristicPlacebo/22, n = 85Placebo/44, n = 87Rx22, n = 167Rx44, n = 167
Values expressed as mean ± SD unless otherwise stated. EDSS = Expanded Disability Status Scale.
* p < 0.05 compared with placebo during PRISMS-2.
Age, y (%)35.8 (7.6)36.6 (7.4)36.7 (6.9)36.9 (7.8)
Number (%) of females62 (72.9)68 (78.2)114 (68.3)110 (65.9)
Duration of MS, y8.5 ± 5.27.6 ± 4.210.0 ± 6.39.9 ± 6.3
EDSS score3.0 ± 1.92.6 ± 1.72.7 ± 1.72.7 ± 1.7
Burden of disease, mm23949 ± 40424091 ± 39682975 ± 3128*3442 ± 3402*
Relapses during PRISMS-22.6 ± 2.12.6 ± 2.01.8 ± 1.7*1.7 ± 1.8*
EDSS score change during PRISMS-20.5 ± 1.10.4 ± 1.10.2 ± 1.20.2 ± 1.1
Median (of mean) T2 lesions per patient per scan during PRISMS-23.03.51.0*0.5*
Percentage of patients progressing during PRISMS-240.039.129.328.1*