Table 4.

Percentages of patients reporting adverse events at least once

Adverse eventYears 1 to 4Years 3 and 4
Rx22, n = 189Rx44, n = 184Placebo/22, n = 85Placebo/44, n = 87Rx22, n = 167Rx44, n = 167
Figures in parentheses are new incident cases plus ongoing cases from the end of year 2.
ALT = alanine transaminase; AST = aspartate transaminase.
Injection-site inflammation737159 (66)62 (66)19 (57)14 (67)
Flu-like symptoms696941 (42)59 (61)48 (50)40 (43)
Rhinitis606134 (39)24 (30)36 (40)29 (34)
Fatigue394421 (34)23 (37)14 (25)12 (28)
Headache697329 (45)32 (55)24 (47)22 (47)
Injection-site reaction354124 (28)33 (38)7 (30)11 (32)
Depression303318 (29)20 (28)14 (23)13 (25)
Myalgia303019 (21)22 (23)13 (16)10 (14)
Fever303012 (14)15 (15)13 (16)10 (12)
Lymphopenia273521 (22)23 (23)16 (20)22 (26)
Elevated ALT level243011 (12)15 (15)11 (14)7 (13)
Elevated AST level11204 (5)8 (9)5 (7)4 (6)
Thrombocytopenia384 (4)1 (1)2 (2)2 (4)