Table 2.

Association of midlife blood pressure and cholesterol levels with MCI later in life

Characteristic% Subjects with MCI, n = 82% Subjects without MCI, n = 1270Odds ratio (95% CI)
Model 1Model 2
Multiple logistic regression analysis was used.
Model 1 gives univariate odds ratios of mild cognitive impairment (MCI), model 2 includes adjusting for age and body mass index.
* Low indicates systolic blood pressure <160 mmHg and cholesterol <6.5 mmol/L; single risk factor, systolic blood pressure ≥160 mmHg or cholesterol ≥6.5 mmol/L; combined, systolic blood pressure ≥160 mmHg and cholesterol ≥6.5 mmol/L.
Cholesterol
<6.5 mmol/L (normal)31.747.61.01.0
≥6.5 mmol/L (high)68.352.42.0 (1.2–3.2)1.9 (1.2–3.0)
Systolic blood pressure
<140 mmHg (normal)43.944.91.01.0
140–159 mmHg (borderline)29.336.20.8 (0.5–1.4)0.8 (0.4–1.3)
≥160 mmHg (high)26.818.91.5 (0.8–2.5)1.2 (0.7–2.2)
Diastolic blood pressure
<90 mmHg (normal)50.052.21.01.0
90–94 mmHg (borderline)19.521.50.9 (0.5–1.7)0.9 (0.5–1.7)
≥95 mmHg (high)30.526.31.2 (0.7–2.0)1.1 (0.7–1.9)
Risk groups*
Low22.040.31.01.0
Single risk factor61.048.02.3 (1.3–4.0)2.2 (1.3–3.9)
Combined risk17.111.72.7 (1.3–5.5)2.3 (1.1–4.8)