Table 2.

Estimated prevalence of neuropathologic AD in different subpopulations and in total genotyped population

APOE genotypeSubpopulationPercentage of subjects with neuropathologic AD in autopsied subpopulationsNo. of subjects on April 1, 1991Estimated no.* of subjects with neuropathologic AD on April 1, 1991Estimated prevalence on April 1, 1991
Age groups in parentheses (<90 y/≥90 y).
* In calculation of the estimated number of subjects with neuropathologic AD, the figure for percentage of subjects with neuropathologic AD in the whole subgroup was used in both age groups because there was no significant difference in proportions of neuropathologic AD between the younger and the older age groups.
VaD = vascular dementia.
ε4−No dementia16 (13/19)260 (208/52)41.60 (33.28/8.32)
Dementia
AD44 (47/42)46 (29/17)20.24 (12.76/7.48)
VaD or other18 (16/23)69 (48/21)12.42 (8.64/3.78)
All375 (285/90)74.26 (54.68/19.58)20 (19/22)
ε4+No dementia42 (43/40)69 (60/9)28.98 (25.20/3.78)
Dementia
AD88 (88/88)41 (27/14)36.08 (23.76/12.32)
VaD or other72 (68/86)47 (37/10)33.84 (26.64/7.20)
All157 (124/33)98.90 (75.60/23.30)63 (61/71)
Total532 (409/123)173.16 (130.28/42.88)33 (32/35)