Table 1.

Demographic, clinical, and conventional MRI characteristics of controls and patients with three different MS clinical phenotypes

CharacteristicsRRMSSPMSPPMS
RRMS = relapsing-remitting MS; SPMS = secondary progressive MS; PPMS = primary progressive MS; EDSS = Expanded Disability Status Scale.
No. of subjects282030
M/F12/168/1216/14
Mean age, y (SD)35.6 (6.3)43.0 (9.3)45.0 (9.2)
Median duration of disease, y (range)5.0 (1.0–12.0)16.0 (5.0–28.0)10.0 (2.0–26.0)
Median EDSS score (range)1.5 (0.0–4.0)6.0 (3.5–7.0)6.0 (3.5–8.5)
Median T2 lesion volume, mL (range)13.0 (0.4–106.9)30.5 (7.9–87.7)16.7 (0.9–60.5)
Median T1-hypointense lesion volume, mL (range)2.5 (0.0–17.8)6.7 (1.9–50.5)3.6 (0.0–19.0)