Table 2.

Comparison of age-adjusted incidence rates to the 1990 US population from selected studies on ALS

RegionYear(s)45–54 y, M/F55–64 y, M/F65–74 y, M/F45–74 y, M/F45–74 y, M+F95% CIM:F rate ratioMean age at diagnosis, y, M/FType of study
* Age groups: 50–59, 60–69, 70–79.
† Age at onset.
‡ Adjusted on 1996 Irish population.
NA = not available; R = retrospective; P = prospective.
Sardinia23*1965 –742.2 /0.93.2 /1.86.6 /1.53.7 /1.42.72.1 –3.42.6:157.7/58.6R
Israel6*1959 –742.1 /1.23.3 /1.82.9 /1.42.7 /1.52.11.8 –2.41.8:157.1/55.6R
Northern Sweden241969 –801.0 /1.07.8 /4.210.0 /5.85.7 /3.54.53.7 –5.51.6:159.0 (M+F)R
Middle Sweden251970 –815.9 /3.29.0 /4.212.3 /6.58.6 /4.56.55.2 –8.11.9:166.0 (M+F)R
Middle Finland261976 –814.6 /5.110.3 /11.813.7 /8.49.0 /8.48.56.1 –11.61.1:160.5/61R
Ontario, Canada201978 –823.0 /2.05.5 /4.09.0 /5.55.4 /3.74.53.7 –5.41.5:162.4/62.7R
Minnesota, USA281925 –842.0 /2.69.5 /5.213.2 /12.67.4 /6.46.84.7 –9.61.2:165.5/68.5R
Southern Sweden22*1961 –902.8 /2.510.8 /6.112.8 /6.27.5 /4.86.15.1 –7.21.6:1NAR
Piemonte, Italy291966 –851.8 /1.33.5 /2.86.8 /3.93.4 /2.22.72.5 –2.91.6:158.1/60.3R
Denmark21*1974 –862.1 /0.85.2 /3.56.2 /5.04.2 /3.03.53.0 –4.11.4:162.4/67.0R
Texas, USA301985 –881.4 /1.35.3 /2.95.0 /7.33.6 /3.63.62.8 –4.51:1NAR
Scotland1319892.8 /0.77.1 /4.612.3 /6.96.7 /3.85.24.1 –6.41.8:162.5/68.0P
Reggio Emilia, Italy311985 –923.2 /2.39.1 /5.49.2 /6.36.7 /4.55.54.3 –7.01.5:160.3/62.8R
Washington, USA141990 –952.5 /3.06.4 /6.110.2 /7.45.8 /5.35.54.7 –6.41.1:157.3/64.5P
Ireland51995 –97NANANA6.7 /5.36.05.1 –6.91.3:164.2/67.8P
Piemonte, Italy, current study1995 –962.1 /1.67.5 /4.710.4 /8.66.1 /4.75.44.6 –6.31.3:163.4/64.3P