Diffusion parameters for different sets of ROI in the NAWM and in the gray matter
Anatomic region | FA, median (range) | VR, median (range) | MD (× 10−3 mm2/s), median (range) | |||
---|---|---|---|---|---|---|
Control subjects | Patients | Control subjects | Patients | Control subjects | Patients | |
Significantly different from controls, Mann–Whitney U test: | ||||||
* p < 0.05; | ||||||
† p < 0.01; | ||||||
‡ p < 0.001; | ||||||
§ p < 0.0001. | ||||||
NAWM = normal-appearing white matter; FA = fractional anisotropy; VR = volume ratio; MD = mean diffusivity. | ||||||
NAWM | ||||||
Anterior limb of internal capsule | 0.64 (0.57–0.70) | 0.61* (0.45–0.70) | 0.54 (0.45–0.6) | 0.58* (0.42–0.78) | 0.82 (0.71–0.96) | 0.79 (0.73–1) |
Genu of internal capsule | 0.68 (0.61–0.67) | 0.67 (0.53–0.75) | 0.49 (0.31–0.6) | 0.51 (0.37–0.68) | 0.79 (0.64–0.93) | 0.79 (0.67–1) |
Posterior limb of internal capsule | 0.68 (0.57–0.8) | 0.68 (0.57–0.83) | 0.44 (0.26–0.65) | 0.47 (0.21–0.63) | 0.77 (0.54–0.9) | 0.71 (0.6–0.9) |
Frontal lobe | 0.59 (0.51–0.66) | 0.54§ (0.42–0.68) | 0.59 (0.46–0.68) | 0.69§ (0.5–0.78)> | 0.84 (0.77–0.9) | 0.90† (0.72–1.4) |
Temporal lobe | 0.60 (0.5–0.75) | 0.54§ (0.37–0.67) | 0.58 (0.37–0.74) | 0.67‡ (0.44–0.84) | 0.80 (0.71–0.9) | 0.83 (0.7–0.99) |
Occipital lobe | 0.58 (0.46–0.71) | 0.53† (0.37–0.72) | 0.62 (0.46–0.77) | 0.68* (0.32–0.82 | 0.82 (0.7–0.93) | 0.79 (0.62–0.95) |
Parietal lobe | 0.64 (0.53–0.72) | 0.58† (0.41–0.7) | 0.54 (0.34–0.69) | 0.61† (0.42–0.81) | 0.82 (0.72–0.97) | 0.81 (0.67–0.99) |
Genu of corpus callosum | 0.77 (0.62–0.88) | 0.76 (0.53–0.9) | 0.34 (0.15–0.6) | 0.34 (0.11–0.65) | 0.82 (0.64–1) | 0.84 (0.63–1.4) |
Splenium of corpus callosum | 0.73 (0.63–0.89 | 0.66† (0.54–0.83) | 0.37 (0.13–0.56) | 0.49† (0.23–0.68) | 0.96 (0.75–1.1) | 1.1‡ (0.76–1.6) |
Cerebral peduncle | 0.70 (0.64–0.8) | 0.68* (0.52–0.81) | 0.42 (0.2–0.6) | 0.46* (0.27–0.61 | 0.84 (0.67–0.97) | 0.87 (0.53–1.7) |
Middle cerebellar peduncle | 0.68 (0.57–0.73) | 0.64 (0.34–0.76) | 0.45 (0.27–0.65) | 0.49 (0.27–0.87) | 0.87 (0.6–1) | 0.88 (0.74–1.2) |
Supratentorial NAWM regions | 0.65 (0.6–0.68) | 0.60§ (0.56–0.64) | 0.50 (0.44–0.57) | 0.55§ (0.49–0.63) | 0.81 (0.76–0.9) | 0.82 (0.75–0.98) |
Infratentorial NAWM regions | 0.69 (0.62–0.76) | 0.66* (0.43–0.75) | 0.43 (0.3–0.6) | 0.49† (0.31–0.64) | 0.86 (0.71–0.97) | 0.88 (0.75–1.3) |
All NAWM regions | 0.65 (0.61–0.69) | 0.62§ (0.56–0.66) | 0.50 (0.42–0.55) | 0.54§ (0.48–0.62) | 0.82 (0.77–0.91) | 0.84 (0.78–0.98) |
Gray matter | ||||||
Caudate nucleus (head) | 0.32 (0.20–0.44) | 0.36* (0.23–0.53) | 0.89 (0.80–0.95) | 0.86* (0.7–0.94) | 0.83 (0.83–1.1) | 0.83 (0.65–0.98) |
Putamen | 0.29 (0.21–0.43) | 0.35† (0.18–0.51) | 0.90 (0.79–0.95) | 0.87† (0.69–0.96) | 0.79 (0.65–1) | 0.75* (0.66–0.88) |
Thalamus (pulvinar) | 0.29 (0.24–0.40) | 0.36† (0.21–0.51) | 0.91 (0.8–0.94) | 0.84† (0.69–0.95) | 0.84 (0.72–1) | 0.82 (0.62–0.99) |
Hippocampus | 0.29 (0.21–0.44) | 0.29 (0.16–0.49) | 0.91 (0.75–0.95) | 0.89 (0.72–0.97) | 0.94 (0.72–1.1) | 0.95 (0.65–1.4) |
Cerebellar gray matter | 0.24 (0.16–0.35) | 0.28 (0.14–0.44) | 0.93 (0.86–0.97) | 0.91 (0.78–0.98) | 0.85 (0.75–1.1) | 0.90 (0.71–1.3) |
All basal ganglia regions | 0.31 (0.24–0.42) | 0.35† (0.24–0.46) | 0.9 (0.81–0.94) | 0.86† (0.75–0.93) | 0.82 (0.7–1) | 0.80 (0.66–0.92) |