Table B1.

Therapeutic Breakout 1 Selegiline

Advantages
As adjunct to levodopa, provides reduced motor fluctuations and increased “on” time
Levodopa-sparing effect
Neuroprotective in laboratory models
May be neuroprotective in PD
Disadvantages
Minimal antiparkinsonian effect
Neuroprotection in PD not established
Does not stop disease progression
Has amphetamine and methamphetamine metabolites