Table B10.

Therapeutic Breakout 10 Transplantation

Advantages
Consistent clinical benefit with some transplant protocols
Consistent increase in striatal FD uptake on PET scan
Implanted cells survive and reinnervate the striatum in an organotypic manner
Does not necessitate making a destructive lesion in the brain
Disadvantages
Necessitates needle passage(s) through the brain, with risk for hemorrhage
Optimal transplant variables not yet defined
Optimal target site not yet defined
Societal and logistic concerns regarding the use of fetal cells
Limited number of centers that can utilize this technology
Reports of disabling dyskinesia need to be clarified