Table 1.

A comparison of the maximum current density (whole cell current amplitude normalized by cell capacitance) of mutant and wild-type calcium channel complexes expressed in COS7 cells

ConstructMutation locationCells recorded, nCells with current, n (%)Current density, pA/pF, mean ± SEM[Ba2+] in bath, mM
Wild type4235 (83)55.97 ± 11.111
3729 (78)81.11 ± 28.2915
R1281XIII S1–S2181 (6)0.401
F1406CIII P loop185 (28)0.88 ± 0.351
7118 (25)1.97 ± 0.4115
R1549XIII–IV164 (25)0.45 ± 0.181