Table 1.

Effects of vigabatrin (VGB) and tiagabine (TGB) on GABA-transaminase activity in isolated regions of rat brain and eye

VGB or TGBCerebellumPonsHippocampusFrontal cortexDorsal cortexVitreous humorRetina
Results are expressed as the mean percentage of the mean control values (± SEM).
ND = not detectable.
VGB
    500 mg/kg72.9 ± 4.386.3 ± 5.275.7 ± 5.474.2 ± 3.574.0 ± 5.3ND71.4 ± 20.0
    1,000 mg/kg59.2 ± 5.468.3 ± 12.160.3 ± 7.768.3 ± 14.753.5 ± 4.2ND21.4 ± 1.0
TGB
    5 mg/kg94.4 ± 10.386.7 ± 7.094.6 ± 11.898.2 ± 12.797.9 ± 13.6ND88.0 ± 12.4
    10 mg/kg95.9 ± 13.085.0 ± 6.693.5 ± 13.393.3 ± 11.6100.8 ± 15.8ND86.8 ± 9.4
    20 mg/kg101.3 ± 10.288.4 ± 7.494.3 ± 13.793.5 ± 9.7108.8 ± 12.3ND99.1 ± 11.2