Table 2.

Effects of vigabatrin (VGB) and tiagabine (TGB) on GABA concentration in isolated regions of rat brain and eye

VGB or TGBCerebellumPonsHippocampusFrontal cortexDorsal cortexVitreous humorRetina
Results are expressed as the mean percentage of the mean control values ± SEM.
ND = not detectable.
VGB
    500 mg/kg129.7 ± 8.9158.7 ± 4.3117.4 ± 2.4123.3 ± 11.4159.1 ± 8.8ND221.0 ± 29.1
    1,000 mg/kg150.6 ± 7.9178.8 ± 10.6140.0 ± 19.7171.7 ± 12.1195.0 ± 14.7ND261.3 ± 68.3
TGB
    5 mg/kg107.8 ± 3.897.2 ± 6.387.6 ± 5.1110.3 ± 8.791.4 ± 7.3ND105.4 ± 23.4
    10 mg/kg102.0 ± 5.390.8 ± 1.9101.2 ± 16.2110.8 ± 7.588.4 ± 6.9ND94.6 ± 16.7
    20 mg/kg98.3 ± 4.2100.0 ± 2.996.2 ± 21.8111.0 ± 5.490.9 ± 6.5ND95.2 ± 13.7