Table 3.

Results of volumetric analysis of each brain region by group (volumes normalized and expressed as mm)

AreaControls (C)ADSDPost hoc analysis
MeanRangeMeanRangeLoss (%)MeanRangeLoss (%)C vs ADC vs SDAD vs SD
a Main effect p < 0.0005.
b Main effect p = 0.002.
c Main effect p = 0.04.
SD = semantic dementia; NS = not significant.
Intracranial area126999876 –150231259010860 –150761272410986 –15412NSNSNS
Area measure of general  brain atrophy63.857.6 –70.857.944.3 –67.8−9.355.941 –67.8−12.4p < 0.0005p < 0.0005NS
Temporal pole
    Lefta97.657.6 –155.792.958.8 –125.7−4.846.226.4 –98−52.7NSp < 0.0005p < 0.0005
    Righta9768.3 –147.291.144.9 –129.1−6.157.424.8 –106.7−40.8NSp < 0.0005p < 0.0005
Amygdala
    Lefta16.112.3 –20.312.67.7 –16.5−21.78.94.8 –15.0−44.7p < 0.0005p < 0.0005p < 0.0005
    Righta16.511.1 –20.913.59.2 –16.9−18.211.27 –20.6−32.1p < 0.001p < 0.0005NS
Hippocampus
    Lefta26.722.6 –34.322.316.3 –31.8−16.419.714.9 –25.1−26.2p < 0.0005p < 0.0005NS
    Righta27.520.6 –35.822.412.5 –33.0−18.523.314.1 –29.8−15.2p < 0.001NSNS
Parahippocampal gyrus
    Lefta32.123.3 –41.527.818.9 –39.5−13.422.113.2 –30.2−31.5NSp < 0.0005NS
    Righta31.722.5 –38.325.410.9 –36.8−19.924.313.7 –35.7−23.3p < 0.0005p < 0.0005NS
Fusiform gyrus
    Lefta34.825.8 –48.929.019.8 –42.8−16.7208.3 –33.4−42.5NSp < 0.0005p < 0.0005
    Righta32.820.0 –45.827.713.2 –36.1−15.523.89.7 –37.0−27.4NSp < 0.0005NS
Inferior and middle  temporal gyrus
    Lefta120.880.8 –159.0104.777.8 –150.8−13.376.930.9 –107.8−36.3NSp < 0.0005p < 0.0005
    Righta127.183.8 –153.5111.153.1 –156.9−12.595.345 –135.2−25NSp < 0.0005NS
Superior temporal gyrus
    Leftb90.859.1 –132.979.354.1 –100.5−12.672.541.8 –115.0−20.2NSNSNS
    Rightc94.174.4 –119.583.240.7 –124.2−11.682.340.7 –124.2−12.5NSNSNS