Table 1.

Serious complications and their outcomes

Patient no.	Clinical scenario	Dose of UK, 10⁶ U	Hospital outcome	Complication
ICA = internal carotid artery; MCA = middle cerebral artery; UK = urokinase.
1	ICA angiographic complication	1.25	Mild disability	Neck hematoma at site of recent surgery
2	MCA angiographic complication	0.5	Severe disability	Large hemorrhagic conversion of left brain infarct; died in nursing home 4 days after discharge
3	MCA angiographic complication	1.0	Died	Large right MCA distribution hematoma, also subdural and subarachnoid blood
4	ICA stroke	1.0	Severe disability	Left basal ganglia hemorrhage with extension into ventricles and subarachnoid space
5	MCA stroke	0.375	Mild disability	Hypotensive (SBP = 63) and bradycardic (HR = 34) during thrombolysis procedure
6	MCA stroke	0.75	Died	Left MCA distribution hemorrhagic infarct
7	MCA stroke	2.25	Moderate disability	Retroperitoneal hematoma
8	MCA stroke	2.25	Died	Right basal ganglia and temporal lobe hemorrhage with extension into the ventricle and subarachnoid space
9	Basilar stroke	0.45	Died	Pontine hemorrhage
10	Basilar stroke	0.5	Severe disability	Epistaxis and groin bleeding
11	Basilar stroke	1.25	Moderate disability	Right thalamic hemorrhage with extension into left lateral ventricle and subarachnoid space
12	Basilar stroke	2.0	Died	Intra/retroperitoneal hematoma requiring exploratory surgery
13	Basilar stroke	2.0	Died	Left subdural hematoma requiring evacuation
14	Basilar stroke	2.25	Died	Left temporal and occipital, right cerebellar, and pontine-midbrain-thalamic hemorrhage
15	Basilar stroke	2.5	Died	Pontine and midbrain hemorrhage
16	Basilar stroke	3.0	Died	Pontine and midbrain hemorrhage