Table 1.

The course of immune factor reactivity in the spinal cord of mutant SOD1 transgenic mice compared with wild-type SOD1 mice

Immune factorAge, d = motor neuron loss
40 = None80 = Minimal120 = Severe
GFAP = glial fibrillary acidic protein; ICAM-1 = intercellular adhesion molecule-1.
Microglia (CD11b)PresentIncreased in ventral hornStrongly increased
IgGIncreasedIncreasedStrongly increased
Fc receptorAbsent/lowIncreasedStrongly increased
ICAM-1IncreasedIncreased in ventral hornStrongly increased
T cells (CD3)AbsentAbsentIncreased
Astrocytes (GFAP)PresentPresentStrongly increased