Table 2.

Duration and severity of withdrawal headache, number of requested rescue medications, and self-assessment of overall state of health in relation to classes of headache drugs for patients with migraine only

Clinical features of withdrawalMedication group, n = 69p Value
T, n = 27E, n = 15A, n = 27T vs AT vs EE vs A
Values are mean ± SD.
T = triptans; E = ergots; A = analgesics; NS = not significant.
No. of headache days4.1 ± 1.96.7 ± 2.49.5 ± 3.5<0.001<0.004<0.022
Mean headache intensity, day 11.6 ± 1.41.2 ± 0.71.4 ± 0.7NSNSNS
Mean headache intensity, day 140.08 ± 0.10.4 ± 0.50.9 ± 0.8<0.001NS<0.004
Mean no. of requested rescue medications0.2 ± 0.41.3 ± 1.12.0 ± 2.0<0.002<0.027NS
Mean self-assessment of overall state of health, day 13.5 ± 1.53.4 ± 1.63.9 ± 1.3NSNSNS
Mean self-assessment of overall state of health, day 141.8 ± 0.82.1 ± 0.93.0 ± 1.1<0.002NS<0.038
Mean no. of days with autonomic symptoms1.0 ± 1.42.6 ± 1.72.9 ± 2.7<0.002<0.020NS