Table 1.

Differential diagnosis of early-onset dementias in Cambridgeshire

Clinical diagnosisAge at appearance of symptoms <65 y, n = 108Age at diagnosis <65 y, n = 88Current age <65 y, n = 60
Values are expressed as n or n (%).
PSP = progressive supranuclear palsy; CBD = corticobasal degeneration; DLB = diffuse Lewy body disease; MSA = multisystem atrophy; PPS = parkinsonism-plus syndromes.
AD27 (25)19 (21.6)11
Frontotemporal dementia17 (15.7)15 (17.0)11
Huntington’s disease21 (19.4)21 (23.9)15
Vascular dementia17 (15.7)11 (12.5)6
Parkinsonian syndromes (PSP, PD, CBD, DLB, MSA, PPS)12 (11.1)9 (10.2)5
Alcohol-related dementia6 (5.6)6 (6.8)5
Secondary dementias5 (4.6)5 (5.7)5
Undetermined3 (2.8)2 (2.3)2