Table 1.

Demographic and neuropsychological profile* in FTD and SemD compared with controls

Profile characteristicsANOVA statisticFTD, mean (SD)SemD, mean (SD)Behavioral controls, mean (SD)
* See Methods for description of tests.
† Not the same group as controls used for neuroimaging (see Methods). Control group is as indicated for all variables except CVLT, for which more behavioral control data are available. For CVLT, behavioral controls are a separate group of 35 subjects (18 men, 17 women, mean age 66.4, range 56–74).
p < 0.05, vs controls.
§ p < 0.05 for ANOVA across groups.
p < 0.05, vs FTD.
FTD = frontotemporal dementia; SemD = semantic dementia; CVLT = California Verbal Learning Test.
Mean age, yF (2,27) = 1.461.867.862.3
Age range, yNA45–7347–8053–74
No. of menNA6105
No. of womenNA225
MMSE (max = 30)F (2,25) = 5.4§23.3 (4.4)22 (7.5)29.5 (0.5)
CVLT free recall; 10 min (max = 9)F (2,47) = 1.83.13 (2.0)2.86 (2.5)4.5 (2.6)
Nonverbal free recall; 10 min (max = 17)F (2,23) = 7.0§5.43 (1.8)5.33 (4.5)10.7 (3.4)
Modified trails
    Time, sF (2,23) = 17.9§110.4 (25.3)70.4 (43.2)25.9 (7.2)
    No. correct (max = 14)F (2,23) = 5.2§7.0 (5.0)9.7 (6.3)14 (0)
    No. of errorsF (2,23) = 5.9§2.7 (2.1)1.0 (1.5)0.3 (0.7)
Phonemic fluency (items in 1 min)
    No. correctF (2,22) = 6.2§7.4 (7.0)7.4 (3.8)15.8 (6.3)
    No. of repetitionsF (2,22) = 1.52.7 (4.9)2.2 (0.5)0.1 (0.3)
    No. of violationsF (2,22) = 4.1§0.0 (0.0)0.9 (1.1)0.1 (0.3)
Semantic fluency (items in 1 min)
    No. correctF (2,24) = 35.8§6.9 (4.6)5.8 (4.2)20 (3.5)
    No. of repetitionsF (2,24) = 2.61.1 (1.4)0.1 (0.3)0.5 (0.9)
    No. of violationsF (2,24) = 0.70.1 (0.4)0.2 (0.7)0 (0)
Design fluency (items in 1 min)
    No. correctF (2,23) = 19.9§3.0 (2.3)5.4 (3.3)11 (2.8)
    No. of repetitionsF (2,23) = 1.80.9 (3.6)2.9 (0.8)1.4 (1.4)
    No. of violationsF (2,23) = 2.91.4 (1.6)0.1 (0.4)0.7 (0.8)
Digit span backwardsF (2,23) = 4.3§3.1 (1.6)4.2 (2.1)5.4 (1.0)
Modified Rey copy (max = 16)F (2,24) = 0.713.1 (2.3)14.8 (3.7)14.3 (2.0)
Picture naming (max = 15)F (2,23) = 36.1§13.5 (4.4)4.6 (1.4)14.4 (1.0)
Sentence comprehension (max = 7)F (2,23) = 2.25.3 (1.8)5.8 (2.3)6.9 (0.3)
Word/phrase repetition (max = 3)F (2,23) = 2.62.7 (0.8)2.2 (1.1)3.0 (0)