Table 3.

Regions of significant atrophy in FTLD, FTD, and SemD compared with controls

Anatomic regionBAX,Y,Zz-Score* (vs con)z-Score FTD < conz-Score SemD < con
* z-Score for the comparison of the FTLD group with controls.
† z-Score at nearest location in the direct comparison of FTD with controls.
‡ z-Score at nearest location in the direct comparison of SemD with controls.
§ p < 0.001, uncorrected.
FTLD = frontotemporal lobar degeneration; FTD = frontotemporal dementia; SemD = semantic dementia; R = right; L = left; BA = Brodman’s area, as indicated by visual inspection the atlas of Talairach and Tournoux and the Duvornoy atlas; NA = no Brodman’s designation.
All FTLD (n = 20) vs controls
    L Ventromedial frontal cortex/subcallosal gyrus25−2,15,−126.34.86.3
    L Medial/posterior orbital gyrus13/14−26,8,−235.63.1§5.9
    R Medial/posterior orbital gyrus13/1423,8,−174.93.6§5.0
    L Posterior insulaNA−44,0,−115.93.4§6.8
    R Anterior insulaNA39,15,−156.06.35.2
    L Anterior insulaNA−38,15,05.34.5§5.0
    L Anterior insulaNA−35,23,−65.15.44.4§
    L Anterior cingulate32−6,50,215.25.34.2§