Table 4.

Regions of significant atrophy in FTD and SemD compared with controls and each other

Anatomic regionBAX,Y,Zz-Score* (vs con)z-Score FTD < SDz-Score SemD < FTD
* z-Score for the comparison of each major diagnostic group (SemD, FTD) with controls.
† z-Score at the nearest location in the direct comparison of SemD with FTD, FTD < SemD contrast.
‡ z-Score at the nearest location in the direct comparison of SemD with FTD, SemD < FTD contrast.
§ p < 0.001, uncorrected, not significant.
FTD = frontotemporal dementia; SemD = semantic dementia; R = right; L = left; BA = Brodman’s area, as indicated by visual inspection the atlas of Talairach and Tournoux and the Duvornoy atlas; NA = no Brodman’s designation; NS = not significant.
FTD (n = 8) vs controls and SemD
    R Anterior insulaNA38,18,−66.34.8NS
    L Anterior insulaNA−38,26,−95.44.2§NS
    R Middle frontal gyrus848,17,325.05.0NS
    L Anterior cingulate32−6,50,235.33.9§NS
    Medial superior frontal gyrus92,57,−24.84.5§NS
    L Premotor cortex6−36,0,575.04.6§NS
SemD (n = 12) vs controls and FTD
    L Anterior inferior temporal gyrus38−29,11,−42>10NS7.4
    R Anterior inferior temporal gyrus3830,11,−426.3NS6.0
    L Posterior amygdala/anterior hippocampusNA−24,−5,−277.5NS7.0
    R Posterior amygdala/anterior hippocampusNA26,−3,−247.5NS6.8
    L Anterior superior temporal gyrus22−51,8,−177.3NS7.0
    R Anterior superior temporal sulcus21/2254,−3,−176.5NS5.3
    L Ventromedial frontal cortex/subcallosal gyrus25−2,15,−126.3NS4.1§