Table 2.

Treatment effects for measures of ADHD, tics and global function

VariableMain effects
CLON vs No CLONMPH vs No MPH
TE95% CIp ValueTE95% CIp Value
Positive values indicate a beneficial effect of the medication. Positive values of TE indicate a beneficial effect of the medication.
ASQ = Conners Abbreviated Symptom Questionnaire; CPT = continuous performance task; Avg. = average; Rxn. = reaction; I/O = inattention/overactivity; O/D = oppositional/defiant; Class. Obs. = classroom observations; C-GAS = Child Global Assessment Scale; CLON = clonidine; MPH = methylphenidate; TE = treatment effect; CI = confidence interval; YGTSS = Yale Global Tic Severity Scale; OI = overall impairment; GTRS = Global Tic Rating Scale; TSSR = Tic Symptom Self-Report.
ADHD measures
    ASQ-Teacher3.2(1.2, 5.2)0.0023.2(1.1, 5.2)0.003
    ASQ-Parent2.5(0.0, 5.0)0.053.3(0.8, 5.9)0.01
    Iowa Conners
        Total2.1(0.2, 4.0)0.032.7(0.7, 4.6)0.009
        I/O1.7(0.5, 2.9)0.0051.8(0.6, 3.0)0.004
        O/D0.4(−0.6, 1.3)0.410.9(0.0, 1.9)0.05
    Classroom Observation
        On Task2.5(−3.7, 8.6)0.438.7(2.5, 14.8)0.007
        Disruptive3.2(−1.0, 7.4)0.131.9(−2.3, 6.2)0.37
    Conners CPT
        Commissions0.7(−3.4, 4.8)0.732.5(−1.7, 6.7)0.24
        Hit Rxn. Time−1.8(−7.3, 3.8)0.52−2.6(−8.3, 3.0)0.36
        Attentiveness1.2(−4.2, 6.5)0.668.1(2.7, 13.5)0.004
        Risk Taking8.2(0.3, 16.1)0.0412.3(4.4, 20.2)0.003
Tic measures
    YGTSS
        Motor1.5(0.1, 2.9)0.030.7(−0.7, 2.1)0.31
        Vocal1.4(−0.1, 2.9)0.061.2(−0.3, 2.7)0.12
        OI3.2(0.0, 6.4)0.052.8(−0.5, 6.0)0.09
        Total6.2(1.1, 11.3)0.024.8(−0.4, 9.9)0.07
    GTRS-Parent1.8(−0.1, 3.7)0.071.7(−0.2, 3.7)0.08
    GTRS-Teacher1.9(0.2, 3.6)0.031.4(−0.3, 3.0)0.11
    TSSR-Parent
        Motor2.4(−0.1, 4.9)0.062.3(−0.2, 4.8)0.08
        Vocal1.3(−0.6, 3.2)0.161.7(−0.2, 3.6)0.08
    TSSR-Teacher
        Motor2.7(0.2, 5.2)0.031.6(−0.9, 4.1)0.20
        Vocal0.4(−1.3, 2.0)0.640.4(−1.2, 2.1)0.61
C-GAS6.9(2.7, 11.1)0.0027.7(3.4, 11.9)0.0005