Table 1.

Comparison of motor cortex metabolites and ratios for patients with ALS and controls

Metabolite or metabolite ratioMean value ± SD (%)
Controls (n = 12)Patients with positive or suspected ALS (n = 12)Patients with possible or definite ALS (n = 16)
The most affected motor cortex was used for patients with ALS, and the average of the left and right motor cortex was used for controls. The percent change is compared with that for controls.
* p < 0.05 (two-tailed t-test).
p < 0.01 (two-tailed t-test).
p < 0.005 (two-tailed t-test).
NAA = N-acetylaspartate; Cre = creatine; Cho = choline.
Most affected motor cortex
    NAA17.2 ± 1.717.7 ± 1.4 (2.9)17.1 ± 2.5 (−0.9)
    Cre7.7 ± 1.08.0 ± 1.2 (3.9)8.2 ± 1.0 (7.2)
    Cho4.4 ± 0.84.7 ± 0.8 (7.7)5.1 ± 0.6 (16.5)*
    NAA/Cre2.14 ± 0.212.07 ± 0.22 (−3.1)1.98 ± (−7.5)*
    NAA/Cho3.76 ± 0.603.60 ± 0.60 (−4.1)3.18 ± (−15.5)
    NAA/(Cro + Cho)1.35 ± 0.151.30 ± 0.15 (−3.5)1.21 ± (−10.6)
Least affected motor cortex
    NAA17.2 ± 1.717.0 ± 1.9 (−1.5)15.9 ± 1.5 (−7.5)*
    Cre7.7 ± 1.07.7 ± 1.0 (0.4)8.0 ± 1.0 (3.6)
    Cho4.4 ± 0.84.5 ± 1.1 (2.67)4.8 ± 0.7 (9.9)
    NAA/Cre2.14 ± 0.213.76 ± 0.30 (−1.2)1.89 ± 0.15 (−11.5)
    NAA/Cho3.76 ± 0.603.55 ± 0.54 (−5.4)3.76 ± 0.36 (−16.2)
    NAA/(Cre + Cho)1.35 ± 0.151.31 ± 0.16 (−2.9)1.17 ± 0.09 (−13.4)#