Table 2.

Longitudinal changes in motor cortex metabolites for nine patients with ALS who were studied at 0, 1, and 3 months

Metabolite or metabolite ratio0 mo1 mo3 mo
The most affected motor cortex was used. The percent change is compared with that at month 0.
Values are expressed as mean ± SD (%).
* p ≤ 0.005 (two-tailed test).
p ≤ 0.05 (two-tailed test).
NAA = N-acetylaspartate; Cre = creatine; Cho = choline.
Most affected motor cortex
    NAA17.7 ± 2.616.4 ± 2.2 (−7.2)15.1 ± 1.3 (−14.5)*
    Cre8.3 ± 0.88.2 ± 1.0 (−0.1)7.3 ± 0.7 (−11.8)*
    Cho5.0 ± 0.65.1 ± 0.6 (1.1)4.1 ± 0.6 (−18.8)*
    NAA/Cre2.1 ± 0.21.9 ± 0.1 (−7.1)2.0 ± 0.1 (−2.7)
    NAA/Cho3.4 ± 0.43.1 ± 0.2 (−8.2)3.5 ± 0.4 (4.7)
    NAA/(Cre + Cho)1.3 ± 0.11.2 ± 0.1 (−7.4)1.3 ± 0.1 (0.1)
Least affected motor cortex
    NAA16.2 ± 2.416.5 ± 2.0 (1.6)16.2 ± 2.1 (−0.3)
    Cre8.0 ± 1.17.9 ± 1.2 (−1.3)7.7 ± 0.6 (−2.9)
    Cho4.5 ± 0.74.8 ± 0.7 (6.2)4.4 ± 0.4 (−2.5)
    NAA/Cre2.0 ± 0.22.0 ± 0.2 (3.3)2.0 ± 0.2 (2.4)
    NAA/Cho3.3 ± 0.43.3 ± 0.4 (−0.9)3.4 ± 0.5 (2.1)
    NAA/(Cro + Cho)1.2 ± 0.11.2 ± 0.1 (1.6)1.2 ± 0.1 (2.4)