Table 2.

Adjusted difference in means (SE) between APOE ε4 genotype groups for each primary outcome neuropsychological examination score at visits 1 and 2

TestMeasurementDifference in test score, visit 1Difference in test score, visit 2
Mean (SE)p ValueMean (SE)p Value
PASAT = paced auditory serial addition task.
Grooved pegboardDominant hand, time, ms−16.3 (5.5)0.005−6.4 (4.2)0.13
Simple reaction timeReaction time, ms−22.4 (32.7)0.496.8 (17.2)0.69
Choice reaction timeReaction time, ms−16.6 (39.3)0.67−12.7 (23.5)0.59
PASATTotal correct, count−9.0 (5.1)0.09−9.0 (5.6)0.12
2.8 s, count−3.3 (1.1)0.004−1.3 (1.0)0.19
Number vigilanceReaction time, ms−26.0 (21.4)0.23−9.8 (15.7)0.54
Dual attentionReaction time, ms−21.0 (25.9)0.42−7.1 (15.1)0.64
StroopSum of times, s−26.2 (22.7)0.25−7.2 (13.8)0.60
Card B, time, s3.1 (4.0)0.441.1 (2.5)0.66
Word recallImmediate recall, count−0.2 (0.5)0.50−0.5 (0.6)0.56
Word recognitionResponse time, ms−177.4 (116.0)0.13−69.4 (99.8)0.49
Picture presentationResponse time, ms−30.6 (98.5)0.76−12.9 (86.7)0.88
Memory scanningResponse time, ms−134.0 (124.3)0.28−67.7 (46.1)0.15