Adjusted difference in means (SE) between APOE ε4 genotype groups for each primary outcome neuropsychological examination score at visits 1 and 2
Test | Measurement | Difference in test score, visit 1 | Difference in test score, visit 2 | ||
---|---|---|---|---|---|
Mean (SE) | p Value | Mean (SE) | p Value | ||
PASAT = paced auditory serial addition task. | |||||
Grooved pegboard | Dominant hand, time, ms | −16.3 (5.5) | 0.005 | −6.4 (4.2) | 0.13 |
Simple reaction time | Reaction time, ms | −22.4 (32.7) | 0.49 | 6.8 (17.2) | 0.69 |
Choice reaction time | Reaction time, ms | −16.6 (39.3) | 0.67 | −12.7 (23.5) | 0.59 |
PASAT | Total correct, count | −9.0 (5.1) | 0.09 | −9.0 (5.6) | 0.12 |
2.8 s, count | −3.3 (1.1) | 0.004 | −1.3 (1.0) | 0.19 | |
Number vigilance | Reaction time, ms | −26.0 (21.4) | 0.23 | −9.8 (15.7) | 0.54 |
Dual attention | Reaction time, ms | −21.0 (25.9) | 0.42 | −7.1 (15.1) | 0.64 |
Stroop | Sum of times, s | −26.2 (22.7) | 0.25 | −7.2 (13.8) | 0.60 |
Card B, time, s | 3.1 (4.0) | 0.44 | 1.1 (2.5) | 0.66 | |
Word recall | Immediate recall, count | −0.2 (0.5) | 0.50 | −0.5 (0.6) | 0.56 |
Word recognition | Response time, ms | −177.4 (116.0) | 0.13 | −69.4 (99.8) | 0.49 |
Picture presentation | Response time, ms | −30.6 (98.5) | 0.76 | −12.9 (86.7) | 0.88 |
Memory scanning | Response time, ms | −134.0 (124.3) | 0.28 | −67.7 (46.1) | 0.15 |