Table 5.

Odds ratios for developing AD according to the −491 A→T, −219 G→T, and APOE genotype ≤81 and >81 years old adjusted for sex, age, and center

Age−491 A→T AA/AT+TT−219 G→T TT/GT+GGAPOE ε4+/ε4−
≤81 years
    Odds ratio1.8 [1.5–2.1]1.5 [1.2–1.7]5.3 [4.4–6.3]
p < 0.0001p < 0.0001p < 0.0001
    Stratification on APOE genotypes
        Without an ε4 allele1.4 [1.1–1.7]1.1 [0.8–1.5]
p < 0.009p < 0.44
        With an ε4 allele1.6 [1.1–2.2]1.1 [0.8–1.4]
p < 0.007p < 0.69
>81 years
    Odds ratio1.4 [1.0–1.8]2.0 [1.5–2.8]3.2 [2.4–4.2]
p < 0.02p < 0.0001p < 0.0001
    Stratification on APOE genotypes
        Without an ε4 allele1.2 [0.9–1.7]1.6 [1.0–2.3]
p < 0.25p <0.03
        With an ε4 allele0.9 [0.5–1.7]1.9 [1.2–3.2]
p < 0.9p < 0.01