Table Clinical evaluation of 60 patients before and after bilateral subthalamic nucleus stimulation

Item (maximal score)MedicationBefore surgeryAfter surgery, on stimulationWilcoxon test
Values are means ± SD. Except for the S&E, a reduction in the scores indicates an improvement in the function.
BDI = Beck Depression Inventory scale; LED = Levodopa equivalent dose in mg/d; NS = not significant; S&E = Schwab and England activities of daily living scale; UPDRS = Unified Parkinson’s Disease Rating Scale.
UPDRS I (16)1.4 ± 1.12.5 ± 2.7NS
UPDRS II (52)“On”11.3 ± 7.811.4 ± 6.4NS
“Off”29.6 ± 8.813.4 ± 9.0p < 0.002
UPDRS III (108)“On”20.3 ± 18.818.8 ± 12.7NS
“Off”53.7 ± 19.124.3 ± 16.6p < 0.002
S&E (100%)“On”77 ± 1883 ± 14NS
“Off”29 ± 1970 ± 26p < 0.002
Dyskinesias (28)“On”9.6 ± 4.05.8 ± 3.0p < 0.001
LED1,010 ± 425522 ± 400p < 0.001
BDI (63)10.5 ± 6.68.5 ± 4.1p < 0.002