Table 1.

Outcome of ALS: Multivariate analysis

VariablesHazard ratiop Value
* Mean number of point lost per month in the 6 months after diagnosis.
Included as time-dependent variable.
FVC = forced vital capacity; PEG = percutaneous endoscopic gastrostomy; MRC = Medical Research Council; EEDC = El Escorial diagnostic criteria.
FVC% progression rate*
    <3%10.0001
    ≥3%5.72
PEG
    Yes10.0004
    No3.89
MRC lower limbs Progression rate*
    <1.510.0011
    ≥1.52.32
Age groups (y)
    ≤5010.007
    51–601.40
    61–701.95
    ≥712.72
Bulbar score Progression rate*
    <0.110.009
    ≥0.11.62
EEDC
    At diagnosis
        Probable + possible + suspected10.01
        Definite1.55
    Riluzole therapy
    Yes10.05
    No1.36