Model no./variable | Regression coefficient | SE | p Value |
---|---|---|---|

* All risk factors at year 2, n = 126. | |||

† All on-study changes, n = 125. | |||

‡ Year 2 MRI, n = 126. | |||

§ MRI on-study changes, n = 125. | |||

EDSS = Expanded Disability Status Scale; MSFC = MS Functional Composite; BPF = brain parenchymal fraction. | |||

1^{*} | |||

Intercept | −2.75 | 0.74 | |

EDSS (year 2) | 0.64 | 0.24 | 0.0070 |

MSFC (year 2) | −0.98 | 0.39 | 0.012 |

2^{†} | |||

Intercept | −1.51 | 0.34 | |

BPF change | −0.42 | 0.22 | 0.056 |

MSFC change | −2.21 | 0.53 | <0.0001 |

3^{‡} | |||

Intercept | 24.39 | 8.06 | |

BPF (year 2) | −31.95 | 9.89 | 0.0012 |

No. of relapses | 0.50 | 0.12 | <0.0001 |

4^{§} | |||

Intercept | −2.15 | 0.37 | |

BPF change | −0.45 | 0.18 | 0.0107 |

No. of relapses | −0.42 | 0.11 | 0.0001 |