Table 1 Metabolic testing in children with global developmental delay

ReferenceClassNResults (% patients with abnormal screening)
33II15126% for mild delay; 77% for severe delay; genetic etiology in 28%, 5% were metabolic disorders
34III1,0870.6%; standardized biochemical screening
35III1,5681.3%; standardized biochemical screening
7III6063% with all testing but less than 1% for metabolic testing
36III281<5%; nonstandardized evaluation; etiologic yield of 72% for whole group
28III99<5% even on an indicated basis
37III11813.6% using stepwise rather than routine screening protocol