Table 3 Least squares means (SE) of overall scores from subject daily diaries: ITT cohort

VariableStudy daysPlacebo, n = 77CR oxycodone, n = 82p Value*
Postbaseline valueChange from baselinePostbaseline valueChange from baseline
* ANCOVA with effects for baseline measurement, center, age group, sex, treatment, study day, treatment by day, and treatment by center.
† 0 (no pain) to 10 (pain as bad as you can imagine).
‡ 1 (not satisfied) to 6 (totally satisfied).
§ Because of the large number of missing baseline values, change from baseline omitted, and baseline satisfaction scores not included in ANCOVA.
∥ 0 (poor sleep) to 10 (excellent sleep).
Average pain intensity1 –275.9 (0.23)−1.0 (0.23)4.9 (0.23)−2.0 (0.23)<0.001
Pain right now1 –425.1 (0.26)−1.1 (0.26)4.1 (0.26)−2.1 (−0.26)0.002
Worst pain1 –426.4 (0.26)−1.3 (0.26)5.4 (0.26)−2.4 (0.26)0.001
Satisfaction with study drug1 –422.4 (0.18)NA§3.4 (0.18)NA<0.001
Sleep quality1 –425.4 (0.24)0.5 (0.24)6.1 (0.24)1.2 (0.24)0.024