Table 4 Least squares means (SE) of overall Brief Pain Inventory scores from days 14 to 42: ITT cohort
| Variable | Placebo, n = 77 | CR oxycodone, n = 82 | p Value* | ||
|---|---|---|---|---|---|
| Postbaseline value | Change from baseline | Postbaseline value | Change from baseline | ||
| * ANCOVA with effects for baseline measurement, center, age group, sex, treatment, study day, treatment by day, and treatment by center. | |||||
| † 0 (no pain) to 10 (pain as bad as you can imagine). | |||||
| ‡ 0% (no relief) to 100% (complete relief). | |||||
| § Mean of general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life scores. | |||||
| ∥ Mean of general activity, walking ability, and normal work scores. | |||||
| ¶ 0 (pain does not interfere) to 10 (pain completely interferes). | |||||
| Average pain intensity† | 5.2 (0.28) | −1.5 (0.29) | 4.2 (0.28) | −2.6 (0.28) | 0.004 |
| Pain right now† | 4.4 (0.28) | −1.6 (0.29) | 3.2 (0.28) | −2.8 (0.29) | <0.001 |
| Worst pain† | 6.2 (0.32) | −1.6 (0.33) | 4.9 (0.32) | −2.9 (0.32) | 0.001 |
| Least pain† | 4.0 (0.26) | −1.1 (0.26) | 3.1 (0.25) | −1.9 (0.25) | 0.004 |
| Pain relief‡ | 36.9 (4.15) | 17.5 (4.24) | 55.8 (4.08) | 37.2 (4.12) | <0.001 |
| Interference score§ | 4.3 (0.27) | −1.8 (0.27) | 3.5 (0.26) | −2.6 (0.26) | 0.015 |
| Physical function score∥ | 4.4 (0.28) | −1.9 (0.29) | 3.8 (0.28) | −2.4 (0.28) | 0.139 |
| General activity¶ | 4.1 (0.29) | −1.8 (0.29) | 3.5 (0.29) | −2.4 (0.29) | 0.075 |
| Mood¶ | 3.7 (0.32) | −2.1 (0.32) | 3.2 (0.32) | −2.6 (0.31) | 0.217 |
| Walking ability¶ | 4.5 (0.32) | −2.0 (0.33) | 4.2 (0.32) | −2.4 (0.33) | 0.337 |
| Normal work¶ | 4.4 (0.31) | −1.9 (0.32) | 3.9 (0.31) | −2.4 (0.31) | 0.237 |
| Relations with other people¶ | 3.2 (0.27) | −1.3 (0.27) | 2.4 (0.27) | −2.0 (0.27) | 0.023 |
| Sleep¶ | 5.3 (0.31) | −1.5 (0.32) | 3.6 (0.32) | −3.3 (0.32) | <0.001 |
| Enjoyment of life¶ | 4.6 (0.32) | −2.2 (0.32) | 3.6 (0.31) | −3.2 (0.31) | 0.016 |