Table 4 Least squares means (SE) of overall Brief Pain Inventory scores from days 14 to 42: ITT cohort

VariablePlacebo, n = 77CR oxycodone, n = 82p Value*
Postbaseline valueChange from baselinePostbaseline valueChange from baseline
* ANCOVA with effects for baseline measurement, center, age group, sex, treatment, study day, treatment by day, and treatment by center.
† 0 (no pain) to 10 (pain as bad as you can imagine).
‡ 0% (no relief) to 100% (complete relief).
§ Mean of general activity, mood, walking ability, normal work, relations with other people, sleep, and enjoyment of life scores.
∥ Mean of general activity, walking ability, and normal work scores.
¶ 0 (pain does not interfere) to 10 (pain completely interferes).
Average pain intensity5.2 (0.28)−1.5 (0.29)4.2 (0.28)−2.6 (0.28)0.004
Pain right now4.4 (0.28)−1.6 (0.29)3.2 (0.28)−2.8 (0.29)<0.001
Worst pain6.2 (0.32)−1.6 (0.33)4.9 (0.32)−2.9 (0.32)0.001
Least pain4.0 (0.26)−1.1 (0.26)3.1 (0.25)−1.9 (0.25)0.004
Pain relief36.9 (4.15)17.5 (4.24)55.8 (4.08)37.2 (4.12)<0.001
Interference score§4.3 (0.27)−1.8 (0.27)3.5 (0.26)−2.6 (0.26)0.015
Physical function score4.4 (0.28)−1.9 (0.29)3.8 (0.28)−2.4 (0.28)0.139
General activity4.1 (0.29)−1.8 (0.29)3.5 (0.29)−2.4 (0.29)0.075
Mood3.7 (0.32)−2.1 (0.32)3.2 (0.32)−2.6 (0.31)0.217
Walking ability4.5 (0.32)−2.0 (0.33)4.2 (0.32)−2.4 (0.33)0.337
Normal work4.4 (0.31)−1.9 (0.32)3.9 (0.31)−2.4 (0.31)0.237
Relations with other people3.2 (0.27)−1.3 (0.27)2.4 (0.27)−2.0 (0.27)0.023
Sleep5.3 (0.31)−1.5 (0.32)3.6 (0.32)−3.3 (0.32)<0.001
Enjoyment of life4.6 (0.32)−2.2 (0.32)3.6 (0.31)−3.2 (0.31)0.016