Table 5 Most frequently reported (≥10% of subjects) adverse events

Adverse eventsPlacebo, n = 77CR oxycodone, n = 82p Value*
Values are n (%).
* Fisher’s exact test.
Constipation11 (14)35 (42)<0.001
Somnolence1 (1)33 (40)<0.001
Nausea6 (8)30 (36)<0.001
Dizziness8 (10)26 (32)<0.001
Pruritus6 (8)20 (24)0.005
Vomiting2 (3)17 (21)<0.001
Dry mouth2 (3)13 (16)0.005
Asthenia5 (7)12 (15)0.125
Headache18 (23)9 (11)0.055