Table 2 Rank correlations of Sloan chart scores (1.25% contrast level) and MSFC component scores with MSFC-3, MSFC-4, and EDSS scores in MS patients from (A) MVP cohort and (B) IMPACT Substudy

A. MVP cohort, single visit,* n = 130, Rank correlation rs
Sloan chartsT25FW9HPTPASAT3MSFC-3MSFC-4EDSS
P < 0.0001 for all correlations except those indicated by † (p = 0.001).
* Z scores for Sloan charts, MSFC-3, and MSFC-4 calculated using group means and standard deviations from single visit (baseline) as reference.
P = 0.001.
Z scores calculated using group means and standard deviations from baseline visit as reference.
Sloan charts = low-contrast Sloan letter charts; T25FW = timed 25-ft walk; 9HPT = 9-hole peg test; PASAT3 = Paced Auditory Serial Addition Test, 3-sec interval; MSFC-3 = Multiple Sclerosis Functional Composite (three components); MSFC-4 = MSFC-3 + Sloan charts; EDSS = Expanded Disability Status Scale; MS = multiple sclerosis; MVP = multiple sclerosis vision prospective.
Sloan charts0.510.540.380.560.77−0.45
T25FW0.670.420.790.79−0.80
9HPT0.410.850.84−0.66
PASAT30.730.67−0.26
MSFC-30.94−0.69
MSFC-4−0.69Sloan chartsRank correlation rs SloanMSFC-3MSFC-4−0.26
B. IMPACT Substudy, 12-mo visit, n = 56, Rank correlation rs
Sloan chartsMSFC-3MSFC-4EDSS
Sloan charts0.570.85−0.43
MSFC-30.88−0.54
MSFC-4−0.56