Table 2 Pharmacokinetics of dopaminergic agents

DrugHalf-life (h)Bioavailability (%)
DDI = Dopa-decarboxylase inhibitor; bioavailability refers to oral administration except for the apomorphine value, which is after SC administration.
Levodopa + DDI1–1.590
Levodopa + carbidopa CR470
Levodopa + benserazide HBS4–660
Apomorphine0.590 (SC)
Bromocriptine12–158
Lisuride1–720
Pergolide15–2720
Cabergoline6460
Piribedil380
Ropinirole6–850
Pramipexole8–1290