Table 2. Comparison of metabolite ratios in WMH and NAWM for those subjects with voxels containing more than 20% WMH

Metabolite ratioNumber of subjectsWMWMHWM vs WMH
MeanSDMeanSDPaired t-test tp (Two-tailed)
WMH = white matter hyperintensity; NAWM = normal-appearing white matter; NAA = N-acetylaspartate; Cr = creatine; Cho = choline.
NAA/Cr91.790.121.800.40−0.060.950
Cho/Cr90.300.040.410.10−3.510.008
NAA/Cho96.390.643.942.333.210.012