StudyPatients with headache before PFO closure, %Effect of PFO closure on migraine with auraEffect of PFO closure on migraine without auraEffect of PFO closure on nonmigraine headaches
Belgian group71% reduction in number of people with headaches50% reduction in number of people with headachesNot tested
    Total39
        Migraine with aura18
        Migraine without aura21
    Nonmigrainousunknown
Swiss group54% decrease in the number of headaches62% decrease in the number of headachesNo significant decrease in nonmigrainous headaches
    Total22
        Migraine with aura17
        Migraine without aura5
    Nonmigrainous11