Table Cox proportional hazard model of the topiramate placebo cohort*

VariableHazard ratio95% Lower CI95% Upper CIp Value
* Adjusted by baseline FVC% and baseline ALSFRS score (i.e. these covariates were included in the calculation of the Cox model, but are not represented in the table as they did not reach significance).
FVC = forced vital capacity; ALSFRS = ALS functional rating scale.
FVC% slope of decline*0.8270.7500.9110.0001
ALSFRS slope of decline*0.5290.3750.7470.0003
Patient age at enrollment, per y1.0381.0181.0590.0002