Table 2 Evidence summary for treatment of acute attacks of migraine

Drug, doses, agesClassnEfficacyAdverse effectsRef.
Active, %Placebo, %p Value
* Exact p values not provided.
† 5 mg dose—66% (p < 0.05), 20 mg dose—63% (p = 0.059).
NSAIDs = non-steroidal anti-inflammatory drugs; NS = nonsignificant.
NSAIDs and nonopiate analgesics
    Ibuprofen
        10 mg/kg (4–16 y)I886837<0.05*Infrequent18
        7.5 mg/kg (6–12 y)I8476530.006Infrequent19
    Acetaminophen 15 mg/kg (4–16 y)I885437<0.05*Infrequent18
Triptans
    Sumatriptan
        Nasal 20 mg (6–14 y)I1485.742.80.03Occasional to frequent20
            5, 10, 20 mg (12–17 y)I51066530.0521
            10, 20 mg (8–17 y)I8364390.00322
        Oral (50, 100 mg (8–16 y)I233022NSOccasional25
        Subcutaneous
            3, 6 mg (6–16 y)IV1764Occasional to frequent23
            0.06 mg/kg (6–18 y)IV507824
    Oral triptans
        Rizatriptan 5 mg (12–17 y)I2966656NSOccasional26
        Zolmitriptan 2.5, 5 mg (12–17 y)IV3885 (2.5 mg)Occasional27
70 (5 mg)