Table 1 Relationship of selected covariates with tHcy and MMSE score among 2,871 baseline community subjects in northern Manhattan

CharacteristicsN (%)tHcyMMSE
tHcy and MMSE values in columns 3 and 4 = mean (SD).
* p < 0.05.
† Cardiac disease = history of atrial fibrillation, myocardial infarction, or coronary artery disease.
‡ MMA > 271 nmol/L is cutpoint for B-12 deficiency.
tHcy = fasting plasma total homocysteine level; MMSE = Mini Mental State Examination; MMA = methylmalonic acid.
Age, y
    >651,822 (65)10.8 (5.5)*25.8 (3.9)*
    ≤651,0499.1 (3.9)26.6 (3.4)
Sex
    Women1,798 (63)9.8 (4.9)*25.8 (3.9)*
    Men1,07010.9 (5.1)26.5 (3.3)
Race ethnicity
    Hispanic1,528 (53)9.8 (5.2)25.3 (3.9)*
    Black675 (24)11.3 (5.1)*26.3 (3.4)*
    White603 (21)10.2 (4.5)27.7 (2.7)
Education
    <High school1,543 (54)10.2 (5.5)24.7 (4.0)*
    ≥High school1,32710.1 (4.5)27.6 (4.5)
Insurance status
    Medicaid957 (33)10.1 (5.3)24.5 (4.2)*
    Medicare or private1,91410.2 (4.9)26.9 (3.1)
Hypertension
    Yes2,106 (73)10.4 (5.3)*25.9 (3.8)*
    No7659.6 (4.3)26.7 (3.4)
Diabetes
    Yes607 (21)9.9 (3.8)25.6 (4.0)*
    No2,26410.3 (5.3)26.2 (3.6)
Cardiac disease
    Yes670 (23)10.9 (5.6)*25.8 (3.9)*
    No2,20110.0 (4.8)26.2 (3.6)
Current smoker
    Yes446 (15)10.5 (4.2)26.5 (3.4)*
    No2,42410.1 (5.2)26.0 (3.8)
Moderate alcohol use
    Yes953 (33)9.8 (4.5)*27.0 (3.1)*
    No1,91410.4 (5.3)25.6 (3.9)
MMA > 271 nmol/L
    Yes476 (17)14.4 (8.7)*25.3 (4.1)*
    No2,395 (83)9.4 (3.3)26.2 (3.4)
Body mass index
    ≥30784 (27)9.8 (4.9)*26.1 (3.5)
    ≥25 <301,197 (42)10.2 (5.0)26.0 (3.8)
    <25 (reference)890 (31)10.5 (5.2)26.2 (3.8)